3-Pyridinecarboxaldehyde → HCID 70391240, compound

HRID 1721892Notes

Reaction equation

HRID 1721892 reaction equation
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[N:11]1[CH:16]=[CH:15][CH:14]=[C:13](C=O)[CH:12]=1>C(O)(=O)C.C(O)C>[C:1]([NH:9][N:10]=[C:15]1[CH:14]=[CH:13][CH:12]=[N:11][CH2:16]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

Participants

5

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 11112Nicotinic acid, hydrazide

Product 1

HCID 70391240HCID 70391240, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 702EthanolSolvent

Procedure

Five drops of glacial acetic acid are added at room temperature to a solution of 41.1 g of nicotinic acid hydrazide and 32.1 g of pyridine-3-carbaldehyde in 300 ml of ethanol. The reaction mixture, which exotherms slightly, is stirred for ca. 2 hours at room temperature. The precipitated product is isolated by filtration, washed with ca. 100 ml of ethanol and dried, affording the title compound of formula ##STR8## with a melting point of 213°-216° C.

Workup

  1. customThe precipitated product is isolated by filtration
  2. washwashed with ca. 100 ml of ethanol
  3. customdried

Sources & evidence

ORD record
ord-bd6d7c50168c429c8e553b724fb7ca98
Source dataset
uspto-grants-1989_08
Patent number
US04853396

Reaction notes

Loading…