Tetrahydrofuran → [1,1-Dimethyl-6-(2-phenylethoxy)hexyl](phenylmethyl)amino-1-[3,5-bis(phenylmethoxy)phenyl]ethanone

HRID 1721958노트

반응식

HRID 1721958 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=1)=[O:4].C([N:30]([CH2:34][CH3:35])C(C)C)(C)C.[CH2:36]1[CH2:40][O:39][CH2:38][CH2:37]1>>[CH3:26][C:21]([CH:2]([NH:30][CH2:34][C:35]1[CH:15]=[CH:14][CH:13]=[CH:18][CH:17]=1)[C:3]([C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=1)=[O:4])([CH3:20])[CH2:22][CH2:23][CH2:24][CH2:36][CH2:40][O:39][CH2:38][CH2:37][C:8]1[CH:7]=[CH:6][CH:5]=[CH:10][CH:9]=1

참가 물질

4

반응물 3

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 1200971-(3,5-Bis(phenylmethoxy)phenyl)-2-bromoethan-1-one

생성물 1

HCID 20029801[1,1-Dimethyl-6-(2-phenylethoxy)hexyl](phenylmethyl)amino-1-[3,5-bis(phenylmethoxy)phenyl]ethanone

실험 절차

A solution of 2-bromo-1-[3,5-bis(phenylmethoxy)phenyl]ethanone (2.5 g), Intermediate 32 (2.0 g) and N,N-diisopropylethylamine (0.77 g) in THF (25 ml) was stirred at room temperature for 2 h and refluxed for 20 h. ER (100 ml) was added and the resulting suspension was filtered, the filtrate was evaporated and the residue was purified by [C] eluting with cyclohexane-ER (4:1) to give the title compound as a pale yellow oil (1.2g). T.l.c. (cyclohexane-ER 3:1) Rf 0.4

후처리

  1. temperaturerefluxed for 20 h
  2. additionER (100 ml) was added
  3. filtrationthe resulting suspension was filtered
  4. customthe filtrate was evaporated
  5. customthe residue was purified by [C]
  6. washeluting with cyclohexane-ER (4:1)

출처 및 근거

ORD 기록
ord-486f7f7af5564834bf73aba0568881ec
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853381

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