反应详情

A solution of 2-bromo-1-[3,5-bis(phenylmethoxy)phenyl]ethanone (2.5 g), Intermediate 32 (2.0 g) and N,N-diisopropylethylamine (0.77 g) in THF (25 ml) was stirred at room temperature for 2 h and refluxed for 20 h. ER (100 ml) was added and the resulting suspension was filtered, the filtrate was evaporated and the residue was purified by [C] eluting with cyclohexane-ER (4:1) to give the title compound as a pale yellow oil (1.2g). T.l.c. (cyclohexane-ER 3:1) Rf 0.4

1. temperaturerefluxed for 20 h
2. additionER (100 ml) was added
3. filtrationthe resulting suspension was filtered
4. customthe filtrate was evaporated
5. customthe residue was purified by [C]
6. washeluting with cyclohexane-ER (4:1)