1,6-Dibromohexane → 1-[3-[(6-Bromohexyl)oxy]propyl]-4-(methylthio)benzene

Participants

Reaction Steps

A mixture of 4-(methylthio)benzenepropanol (5.0 g), 1,6-dibromohexane (17.0 g), TAB (0.4 g) and aqueous sodium hydroxide (50% w/v, 20 ml) was stirred for 20 h, diluted with water (30 ml), and extracted with ether (2×100 ml). The dried extract was evaporated and the residue was purified by FCC eluting with cyclohexane followed by System A (19:1) to give the title compound as a colourless oil (7.0 g), T.l.c. (System A 9:1) Rf 0.5.

Provenance & Evidence