反应详情

A mixture of 4-(methylthio)benzenepropanol (5.0 g), 1,6-dibromohexane (17.0 g), TAB (0.4 g) and aqueous sodium hydroxide (50% w/v, 20 ml) was stirred for 20 h, diluted with water (30 ml), and extracted with ether (2×100 ml). The dried extract was evaporated and the residue was purified by FCC eluting with cyclohexane followed by System A (19:1) to give the title compound as a colourless oil (7.0 g), T.l.c. (System A 9:1) Rf 0.5.

1. extractionextracted with ether (2×100 ml)
2. extractionThe dried extract
3. customwas evaporated
4. customthe residue was purified by FCC
5. washeluting with cyclohexane