1,6-Dibromohexane → 1-[3-[(6-Bromohexyl)oxy]propyl]-4-(methylthio)benzene

HRID 1721959노트

반응식

HRID 1721959 반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][OH:12])=[CH:5][CH:4]=1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]Br.[OH-].[Na+]>O>[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:12][CH2:11][CH2:10][CH2:9][C:6]1[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=1

참가 물질

5

반응물 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 122566073-(4-Methylsulfanyl-phenyl)-propan-1-OL

생성물 1

HCID 198627191-[3-[(6-Bromohexyl)oxy]propyl]-4-(methylthio)benzene수율 73.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4-(methylthio)benzenepropanol (5.0 g), 1,6-dibromohexane (17.0 g), TAB (0.4 g) and aqueous sodium hydroxide (50% w/v, 20 ml) was stirred for 20 h, diluted with water (30 ml), and extracted with ether (2×100 ml). The dried extract was evaporated and the residue was purified by FCC eluting with cyclohexane followed by System A (19:1) to give the title compound as a colourless oil (7.0 g), T.l.c. (System A 9:1) Rf 0.5.

후처리

  1. extractionextracted with ether (2×100 ml)
  2. extractionThe dried extract
  3. customwas evaporated
  4. customthe residue was purified by FCC
  5. washeluting with cyclohexane

출처 및 근거

ORD 기록
ord-f6d5c1e749ba43b1aac77a77defdf820
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853381

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