Dimethylamine → HCID 178483903, compound

HRID 1721980Notes

Reaction equation

HRID 1721980 reaction equation
[O:1]1[CH2:20][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)=[CH:7][CH:6]=1.[CH3:21][NH:22][CH3:23]>C(N(CC)CC)C>[CH3:21][N:22]([CH3:23])[CH2:20][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 178506251HCID 178506251, compound

Product 1

HCID 178483903HCID 178483903, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A solution of 2-[4-(2,3-epoxypropoxy) phenyl]-4-trifluoromethylimidazole in triethylamine (15 ml) is added 1.1 equivalents of a dimethylamine. This solution is refluxed until reaction is complete as indicated by TLC. The solvent is removed under reduced pressure and the residue recrystallized to yield 2-[4-(3-dimethylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole.

Workup

  1. temperatureThis solution is refluxed until reaction
  2. customThe solvent is removed under reduced pressure
  3. customthe residue recrystallized

Sources & evidence

ORD record
ord-83a3ecf085a34216b15370f19fbccecf
Source dataset
uspto-grants-1989_08
Patent number
US04853383

Reaction notes

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