反应详情

In a polyethylene bottle were combined 3.3 g (13 mmol) 3-(4-chloro-3-methoxyphenoxy)butyric acid and 30 ml liquid hydrogen fluoride. The reaction mixture was allowed to stand at 23° C. for 72 hours, then poured over ice and extracted with 2×100 ml diethyl ether. The ether was washed with 2×100 ml water, 100 ml saturated sodium bicarbonate and brine, dried over magnesium sulfate and concentrated in vacuo to give the product as a yellow solid, 2.7 g (93%).

1. additionpoured over ice
2. extractionextracted with 2×100 ml diethyl ether
3. washThe ether was washed with 2×100 ml water, 100 ml saturated sodium bicarbonate and brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo