3-Chlorophenol → HCID 20030203, compound

HRID 1722049Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Cl[C:10]1[CH:11]=[C:12]([OH:16])C=C[CH:15]=1.FC1C=C(O)C=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:12](=[O:16])[CH2:11][CH:10]([CH3:15])[O:8]2)=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 79333-Chlorophenol

HCID 97433-Fluorophenol

HCID 115633-Bromophenol

Product 1

HCID 20030203HCID 20030203, compoundYield 30%

Procedure

By the method of Preparations L1 and L2, and 3-bromophenol, 3-chlorophenol and 3-fluorophenol were converted, respectively, to 7-bromo-2-methylchroman-4-one (30% yield; oil); 7-chloro-2-methylchroman-4-one (35% yield; oil;

Sources & evidence

ORD record: ord-bfe2d5a4d48740c39ba892393a0d378c
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04853410

Reaction notes

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