Hydrazine hydrate (1:1) → HCID 86741570, compound

HRID 1722140Notes

Reaction equation

HRID 1722140 reaction equation
[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:14])[CH3:13])[CH2:8][CH2:7]1)=O.O.[NH2:21][NH2:22]>C(O)C>[C:12]([N:9]1[CH2:10][CH2:11][CH:6]([C:4](=[N:21][NH2:22])[C:3]2[CH:15]=[CH:16][C:17]([F:19])=[CH:18][C:2]=2[F:1])[CH2:7][CH2:8]1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Product 1

HCID 86741570HCID 86741570, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 15.0 g of 4-(2,4-difluorobenzoyl)-1-acetylpiperidine, 6.9 g of hydrazine hydrate and 140 ml of ethanol was heated under reflux for 4 hrs. The ethanol was removed in vacuo to give a solid. The solid was triturated with water, filtered and dried to yield 12.5 g (64%) of 1-acetyl-4-(2,4-difluorobenzoyl)piperidine hydrazone, mp 139°-142° C.

Workup

  1. temperatureunder reflux for 4 hrs
  2. customThe ethanol was removed in vacuo
  3. customto give a solid
  4. customThe solid was triturated with water
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-46dcd03c516e427c99cd83bc35562afd
Source dataset
uspto-grants-1989_08
Patent number
US04853470

Reaction notes

Loading…