Sodium Hydroxide → HCID 20028502, compound

HRID 1722260Notes

Reaction equation

HRID 1722260 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH2:12][CH2:13][CH2:14][CH:15]([CH2:22][O:23][CH2:24][CH3:25])[C:16]=3[C:17]=2[C:18]=1[CH2:19][O:20][CH3:21])=[O:5])C.[OH-].[Na+]>C(O)C.Cl>[CH2:24]([O:23][CH2:22][CH:15]1[CH2:14][CH2:13][CH2:12][C:11]2[NH:10][C:9]3[CH:8]=[N:7][C:6]([C:4]([OH:5])=[O:3])=[C:18]([CH2:19][O:20][CH3:21])[C:17]=3[C:16]1=2)[CH3:25]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 53931798HCID 53931798, compound

Product 1

HCID 20028502HCID 20028502, compoundYield 104.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

5,6,7,8-Tetrahydro-5-ethoxymethyl-4-methoxymethyl-betacarboline-3-carboxylic acid ethyl ester (0.51 g) is refluxed in ethanol (25 ml) with 1 normal sodium hydroxide solution (4.3 ml) for 3 hours. Then the solution is mixed with 5.3 ml of IN hydrochloric acid and evaporated. The residue is boiled out with ethanol, 0.49 g of 5,6,7,8-tetrahydro-5-ethoxymethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid is obtained from the ethanol extract after treatment with carbon by evaporation. Melting point, 250° C. (decomposition).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-d25b355c47ba4ca4b16d4df45be43f88
Source dataset
uspto-grants-1989_08
Patent number
US04855295

Reaction notes

Loading…