反应详情

Ethyl 2-(2,3,6-trifluorophenyl)acetate (16.2 g) is dissolved in ethanol (60 ml). The mixture is stirred and thereto is added 3N sodium hydroxide (200 ml), and the mixture is stirred at 70° C. for one hour. After cooling, 6N hydrochloric acid (120 ml) is added to the mixture. The resulting white powdery precipitates are dissolved by adding thereto diethyl ether. The diethyl ether layer is separated and dried over magnesium sulfate and then concentrated under reduced pressure to give 2-(2,3,6-trifluorophenyl)acetic acid (13.9 g), as white crystals.

1. stirringthe mixture is stirred at 70° C. for one hour
2. temperatureAfter cooling
3. customThe resulting white powdery precipitates
4. dissolutionare dissolved
5. additionby adding
6. customThe diethyl ether layer is separated
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated under reduced pressure