反应详情

A mixture of 2.3 g of 5-methoxy-3-(4-piperidinyl)-1H-indole, 2.58 g of 8-[4-chlorobutyl-8-azaspiro[4,5]decane-7,9-dione, 2.12 g of sodium carbonate, 150 mg of sodium iodide and 50 ml of butanone was refluxed under an inert atmosphere with stirring for 20 hours and after another 1.29 g of the dione were added. Reflux was continued for 6 hours. The mixture was filtered and washed with acetone and the filtrate was evaporated to dryness. The residue was crystallized from 60% ethanol to obtain 3.4 g of 8-[4-{4-(5-methoxy-1H-indol-3-yl)-1-piperidinyl}-butyl]-8-azaspiro[4,5]decane-7,9-dione melting at ≈150° C.

1. temperaturewas refluxed under an inert atmosphere
2. additionafter another 1.29 g of the dione were added
3. temperatureReflux
4. waitwas continued for 6 hours
5. filtrationThe mixture was filtered
6. washwashed with acetone
7. customthe filtrate was evaporated to dryness
8. customThe residue was crystallized from 60% ethanol