反应详情

温度

55 °C

To 3ml of methanol is added 0.1g (0.21 mmol) of the titled product of Example 12 and 10mg of p-toluenesulfonic acid. The reaction mixture is heated to 55°C. for 3 hours. The solvent was removed under reduced pressure and the residue was flash chromatographed on silica gel column. Elution with 2:1 diethyl ether hexane produced 3 bands. The third band contained 0.30g of the titled products which was collected as fractions 8-18.

1. customThe solvent was removed under reduced pressure
2. customchromatographed on silica gel column
3. washElution with 2:1 diethyl ether hexane
4. customproduced 3 bands
5. customwas collected as fractions 8-18