Methylamine → HCID 178484960, compound

HRID 1722439Notes

Reaction equation

HRID 1722439 reaction equation
Br.Cl.[Cl:3][CH2:4][CH2:5][NH2:6].[C:7]([NH:9][C:10](=[N:13][CH2:14]CCl)OC)#[N:8].CN>>[C:7]([NH:9][C:10]([NH:13][CH3:14])=[N:6][CH2:5][CH2:4][Cl:3])#[N:8]

Participants

4

Reactant 3

HCID 6329MethylamineHCID 13527542Methyl N'-(2-chloroethyl)-N-cyanocarbamimidateHCID 86743287HCID 86743287, compound

Product 1

HCID 178484960HCID 178484960, compound

Procedure

Dimethyl-(N-cyanoimido)carbonate is a known compound. Its preparation was described e.g. in J. Org. Chem. 1974, 39, 1522. According to the process of Yugoslavian Application No. P-2151/83, dimethyl-(N-cyanoimido)carbonate is reacted with chloroethylamine hydrochloride hydrobromide to N-cyano-N'-(2-chloroethyl)-O-methyl-isourea, which is reacted with methylamine to yield the N-cyano-N'-methyl-N"-(2-chloroethyl)guanidine.

Workup

  1. customIts preparation

Sources & evidence

ORD record
ord-3a09319402e442888fee8e46e2eb4b85
Source dataset
uspto-grants-1989_08
Patent number
US04855439

Reaction notes

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