Retinoyl beta-glucuronide → Glucuronic Acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Retinoyl beta-glucuronide	HCID 5281877	—
Edukt	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl fluoride	HCID 5378594	—
Produkt	Glucuronic Acid	HCID 65041	—

Reaktionsschritte

The first chemical synthesis of retinoyl β-glucuronide was reported by us (Barua & Olson, J. Lipid Res. 26: 1277-1282, 1985), and involves a two-step procedure. Retinoyl fluoride was allowed first to react with 6,3-glucuronolactone to produce the 6,3-lactone of retinoyl glucuronic acid, which was then hydrolysed with very dilute alkali to give retinoyl β-glucuronide. The present invention is an improvement over the two-step procedure.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04855463
Quelldatensatz	uspto-grants-1989_08
ORD ID	ord-783443e65d52400c99d916c2b1b555e8
Quellennotiz	uspto-grants-1989_08