Permanganate → Ibuprofen, (+-)-

HRID 1722553Notes

Reaction equation

[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:14])[CH:12]=[O:13])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[Mn]([O-])(=O)(=O)=[O:16].Cl[O-]>>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([CH3:14])[C:12]([OH:16])=[O:13])=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

Participants

Reactant 3

HCID 24401Permanganate

HCID 61739Hypochlorite

HCID 595156Ibuprofenal

Product 1

HCID 3672Ibuprofen, (+-)-

Procedure

After the hydroformylation, the obtained α-(4-isobutylphenyl)propionaldehyde is oxidized by the conventional method using, for example, permanganate or hypochlorite to obtain the ibuprofen, α-(4-isobutylphenyl)propionic acid.

Sources & evidence

ORD record: ord-be3aef9529104a10a5a102743f4e7e9b
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04855519

Reaction notes

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