Methyl iodide → HCID 20028883, compound

HRID 1722586Notes

Reaction equation

HRID 1722586 reaction equation
[CH2:1]([C:4]1[N:13]=[C:12]([SH:14])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH2:2][CH3:3].[OH-].[Na+].[CH3:17]I>O>[CH3:17][S:14][C:12]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:1][CH2:2][CH3:3])[N:13]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178440258HCID 178440258, compound

Product 1

HCID 20028883HCID 20028883, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-propyl-4-mercaptoquinazoline (3.3 g.) and sodium hydroxide (0.68 g.) in water (7 ml.) was stirred for 10 minutes at 25°. Methyl iodide (1.1 ml.) was added and stirring was continued for 1 hour. The precipitate was recrystallised from hexane to give 4-methylthio-2-propylquinazoline; n.m.r. in CDCl3 :-1.1(t, 3H); 1.95(m, 2H); 2.7(s, 3H); 3.0(t, 2H); 7.2-8.1(complex, 4H).

Workup

  1. stirringstirring
  2. waitwas continued for 1 hour
  3. customThe precipitate was recrystallised from hexane

Sources & evidence

ORD record
ord-34d8da638c704ea8bfc5bff4a787ff04
Source dataset
uspto-grants-1989_08
Patent number
US04855420

Reaction notes

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