Sodium Hydroxide → HCID 14213088, compound

HRID 1722678Notes

Reaction equation

HRID 1722678 reaction equation
[N:1]1([C:7]([NH:9][CH:10]([C:16]([CH3:24])([CH3:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]([O:13]CC)=[O:12])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[OH-].[Na+]>O1CCOCC1.O>[N:1]1([C:7]([NH:9][CH:10]([C:16]([CH3:24])([CH3:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]([OH:13])=[O:12])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 14213086HCID 14213086, compound

Product 1

HCID 14213088HCID 14213088, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
35 °C

Procedure

A solution of the product from Example 115 (2 g, 5.99 mmol) in dioxane (10 ml) was treated with 0.26 g (6.5 mmol) of sodium hydroxide in 5 ml of water. After stirring for 16 h at 35° C., the reaction was worked up as described in Example 114 to give a 93% yield of product.

Sources & evidence

ORD record
ord-a2a581098dcc4e3b8ffd34b8b4106c62
Source dataset
uspto-grants-1989_08
Patent number
US04857507

Reaction notes

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