Hydrochloric Acid → HCID 15631263, compound

HRID 1722683Notes

Reaction equation

HRID 1722683 reaction equation
C[O:2][C:3](=[O:24])[C@H:4]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[NH:5][C:6]([N:8]([CH2:10][CH:11]([OH:14])[CH2:12][OH:13])[CH3:9])=[O:7].Cl>O1CCOCC1.O>[CH3:9][N:8]([CH2:10][CH:11]([OH:14])[CH2:12][OH:13])[C:6]([NH:5][C@H:4]([C:3]([OH:24])=[O:2])[CH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)=[O:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 15631261HCID 15631261, compound

Product 1

HCID 15631263HCID 15631263, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

The resultant compound from Example 129 (114 mg, 0.355 mmol) in dioxane (4 m) and water (2 ml) at 0° C. was treated with LiOH monohydrate (42.0 mg, 1 mmol). After 90 min 2 M HCl (0.6 ml, 2.3 mmol) was added and the mixture was evaporated to a foam which was used without further purification; DCI-MS: (M+H)+ =327.

Workup

  1. customthe mixture was evaporated to a foam which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-9592e1229cb6412aa7cce7c339016671
Source dataset
uspto-grants-1989_08
Patent number
US04857507

Reaction notes

Loading…