HCID 85581007, compound → HCID 14232072, compound

HRID 1722690Notes

Reaction equation

HRID 1722690 reaction equation
[N:1](=[C:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])O>C(O)(=O)C.[Pt]=O>[NH2:1][CH:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 1

HCID 85581007HCID 85581007, compound

Product 1

HCID 14232072HCID 14232072, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

12.8 g of oxime from Example I (3) are dissolved in 128 ml of glacial acetic acid, 1.3 g of platinum oxide are added and the mixture is hydrogenated in an autoclave under a hydrogen pressure of 10 atmospheres for 8 hours. After the catalyst has been filtered off with suction, the filtrate is concentrated in vacuo, the residue is taken up in methylene chloride and the mixture is extracted with 2N aqueous HCl. The HCl phase is rendered basic with sodium hydroxide solution and extracted with methylene chloride.

Workup

  1. customfor 8 hours
  2. filtrationAfter the catalyst has been filtered off with suction
  3. concentrationthe filtrate is concentrated in vacuo
  4. extractionthe mixture is extracted with 2N aqueous HCl
  5. extractionextracted with methylene chloride

Sources & evidence

ORD record
ord-f8c9b4ed6b4f4cf3a86f8fb14872c81e
Source dataset
uspto-grants-1989_08
Patent number
US04857520

Reaction notes

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