HCID 85581007, compound → HCID 14232072, compound

Participants

Reaction Steps

12.8 g of oxime from Example I (3) are dissolved in 128 ml of glacial acetic acid, 1.3 g of platinum oxide are added and the mixture is hydrogenated in an autoclave under a hydrogen pressure of 10 atmospheres for 8 hours. After the catalyst has been filtered off with suction, the filtrate is concentrated in vacuo, the residue is taken up in methylene chloride and the mixture is extracted with 2N aqueous HCl. The HCl phase is rendered basic with sodium hydroxide solution and extracted with methylene chloride.

Provenance & Evidence