Ethylmorpholine → HCID 14232075, compound

Participants

Reaction Steps

4.1 g of amino acid hydrochloride from Example I (5) are suspended in 40 ml of methylene chloride, 12.8 ml of N-ethylmorpholine are added, while cooling with ice, and 12.8 ml of 50% strength n-propanephosphonic acid anhydride in methylene chloride are added dropwise at 0° C. The solution is left to stand at room temperature for 14 hours. It is then diluted with 200 ml of CH2Cl2 and extracted with water, 2N HCl and saturated NaHCO3 solution. The CH2Cl2 phase is dried and evaporated.

Provenance & Evidence