Ethylmorpholine → HCID 14232075, compound

HRID 1722691Notes

Reaction equation

HRID 1722691 reaction equation
[NH2:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O.C(N1CCOCC1)C>C(Cl)Cl>[O:12]=[C:10]1[NH:1][CH:2]2[CH2:6][CH2:5][CH2:4][CH:3]2[CH2:7][CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 7525EthylmorpholineHCID 14232073HCID 14232073, compound

Product 1

HCID 14232075HCID 14232075, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

4.1 g of amino acid hydrochloride from Example I (5) are suspended in 40 ml of methylene chloride, 12.8 ml of N-ethylmorpholine are added, while cooling with ice, and 12.8 ml of 50% strength n-propanephosphonic acid anhydride in methylene chloride are added dropwise at 0° C. The solution is left to stand at room temperature for 14 hours. It is then diluted with 200 ml of CH2Cl2 and extracted with water, 2N HCl and saturated NaHCO3 solution. The CH2Cl2 phase is dried and evaporated.

Workup

  1. additionare added dropwise at 0° C
  2. waitThe solution is left
  3. extractionextracted with water, 2N HCl and saturated NaHCO3 solution
  4. dry with materialThe CH2Cl2 phase is dried
  5. customevaporated

Sources & evidence

ORD record
ord-f4ca36b032cd4dc2b2bd1158a5086167
Source dataset
uspto-grants-1989_08
Patent number
US04857520

Reaction notes

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