反应详情

5-{5-[4-(2-Furanyl)phenoxy]pentyl}-3-methylisoxazole [II; R1 and R2 =H, Het=2-furanyl] was prepared from 3.6 g 4-(2-furanyl)phenol (m.p. 128-129° C., King and Walton, Synthesis 1976, p. 40), 5.4 g 5-(5-bromopentyl)-3-methylisoxazole and 1.5 g potassium hydroxide in acetonitrile according to the procedure of Example 1, part (c), and was obtained (4.2 g) as a light-tan solid, m.p. 86-88° C. when recrystallized from isopropyl acetate.

1. customwas obtained (4.2 g) as a light-tan solid, m.p. 86-88° C. when
2. customrecrystallized from isopropyl acetate