Hydrochloric Acid → 3-(2-Morpholinoethylcarbamoyl)-methyl-4-(3-nitrophenyl)-6-phenylpyridine dihydrochloride

HRID 1722790Notes

Reaction equation

HRID 1722790 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10]([C:12]2[C:13]([CH3:33])=[N:14][C:15]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:16][C:17]=2[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[CH:19]=2)=[O:11])[CH2:3][CH2:2]1.[ClH:34].O>C(O)C>[ClH:34].[ClH:34].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][C:10]([C:12]2[C:13]([CH3:33])=[N:14][C:15]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[CH:16][C:17]=2[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[CH:19]=2)=[O:11])[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 3082657FR 76830

Product 1

HCID 200714953-(2-Morpholinoethylcarbamoyl)-methyl-4-(3-nitrophenyl)-6-phenylpyridine dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3-(2-morpholinoethylcarbamoyl)-methyl-4-(3-nitrophenyl)-6-phenylpyridine (3 g) in ethanol (60 ml) was added concentrated hydrochloric acid (1.68 ml) and water (3.32 ml). The separated crystal was filtered, washed with ethanol (20 ml) and dried in vacuo to give 3-(2-morpholinoethylcarbamoyl)-methyl-4-(3-nitrophenyl)-6-phenylpyridine dihydrochloride (2.91 g).

Workup

  1. filtrationThe separated crystal was filtered
  2. washwashed with ethanol (20 ml)
  3. customdried in vacuo

Sources & evidence

ORD record
ord-881e6c4f3dba4fed81b2f4058f1f5e1e
Source dataset
uspto-grants-1989_08
Patent number
US04857527

Reaction notes

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