3-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanal → HCID 14989159, compound

HRID 1722803Notes

Reaction equation

HRID 1722803 reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([S:16][CH2:17][CH2:18][CH:19]=[O:20])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])[CH3:3].[CH:21]1([Mg]Br)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>O1CCCC1>[CH3:15][C:12]([C:9]1[CH:8]=[C:7]([S:16][CH2:17][CH2:18][CH:19]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[OH:20])[CH:6]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[C:10]=1[OH:11])([CH3:13])[CH3:14]

Participants

4

Reactant 2

HCID 140118163-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanalHCID 178419651HCID 178419651, compound

Product 1

HCID 14989159HCID 14989159, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By the method of Example 14, the aldehyde of Example 4 was reacted with 7.1 ml of 1.97M cyclohexyl magnesium bromide in tetrahydrofuran to give the title alcohol. Analysis calc. for C23H38O2S(378.60):

Sources & evidence

ORD record
ord-037096b25f074fd7a1165a39df9acae2
Source dataset
uspto-grants-1989_08
Patent number
US04857558

Reaction notes

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