反应详情

The bromide from Example 12 (4.5 g, 14.4 mmol) was reacted with 2,4-dihydroxy-3-propylacetophenone (2.9 g, 15.0 mmol) in methyl ethyl ketone (45 ml) containing anhydrous K2CO3 (4.0 g, 29.0 mmol) at reflux temperature for 6 hours in an atmosphere of nitrogen. The mixture was filtered, concentrated in vacuo and the residue was purified by chromatography on silica gel to provide the title compound, m.p. 88.5°-89.5° C.

1. temperatureat reflux temperature for 6 hours in an atmosphere of nitrogen
2. filtrationThe mixture was filtered
3. concentrationconcentrated in vacuo
4. customthe residue was purified by chromatography on silica gel