Methanol → HCID 23707314, compound

HRID 1722842Notes

Reaction equation

HRID 1722842 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([C@H:21]3[O:25][C:24](=[O:26])[CH2:23][C@H:22]3[CH3:27])=[CH:17][CH:16]=2)=[C:6]([CH2:28][CH2:29][CH3:30])[C:5]=1[OH:31])(=[O:3])[CH3:2].[OH-:32].[Na+:33].CO>C1COCC1>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]([OH:25])[CH:22]([CH3:27])[CH2:23][C:24]([O-:26])=[O:32])=[CH:17][CH:16]=2)=[C:6]([CH2:28][CH2:29][CH3:30])[C:5]=1[OH:31])(=[O:3])[CH3:2].[Na+:33]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57016180HCID 57016180, compound

Product 1

HCID 23707314HCID 23707314, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The lactone from Example 13 (3.0 g, 7.0 mmol) was hydrolyzed with 1N NaOH (10.5 ml), methanol (1 ml) and THF (15 ml) at room temperature for 15 hours. The mixture was concentrated and the residue was Purified by chromatography on XAD-8 to provide the title compound as a foam.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was Purified by chromatography on XAD-8

Sources & evidence

ORD record
ord-100f47aaff78495ba27501271a6f91ea
Source dataset
uspto-grants-1989_08
Patent number
US04857659

Reaction notes

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