反应详情

To a solution of 1.40 g of sarcosine methyl ester hydrochloride in 50 ml of dichloromethane were added 1.54 ml of triethylamine and 1.70 g of the 2-(1-naphthylmethylene)succinic anhydride obtained, and the mixture was stirred for 30 minutes at room temperature. The reaction mixture was washed successively, with diluted hydrochloric acid, and a saturated sodium chloride aqueous solution, dried over anhydrous magnesium, and concentrated under reduced pressure. The residue was purified by silica gel flash column chromatography (eluent: chloroform) to obtain 2.37 g of 2-(1-naphthylmethylene)-3-(N-methyl-N-methoxycarbonylmethylcarbamoyl)propionic acid as a white powder.

1. customobtained
2. washThe reaction mixture was washed successively, with diluted hydrochloric acid
3. dry with materiala saturated sodium chloride aqueous solution, dried over anhydrous magnesium
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel flash column chromatography (eluent: chloroform)