反应详情

A solution of 300 mg of 2-(1-naphthylmethylene)succinic anhydride and 18 ml of methyl alcohol in 30 ml of dry dichloromethane was heated under reflux for 5 hours. The reaction mixture was washed successively with a diluted hydrochloric acid and water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 336 mg of 3-methoxycarbonyl-2-(1-naphthylmethylene)propionic acid as a white powder.

1. temperatureunder reflux for 5 hours
2. washThe reaction mixture was washed successively with a diluted hydrochloric acid and water
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure