HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-amino-2-ethylcrotonate → Ethyl 2-ethyl-3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-crotonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-amino-2-ethylcrotonate | HCID 10630766 | — |
| Reactant | 4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate | HCID 13272924 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-ethyl-3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-crotonate | HCID 70395854 | — |
Reaction Steps
using 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate in dimethylformamide with ethyl 3-amino-2-ethylcrotonate there is obtained ethyl 2-ethyl-3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-crotonate, m.p. 112°-114° C. and from this intermediate with sodium hydride in dimethylformamide there is obtained 5-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-methyl-2,4(1H,3H)-pyrimidinedione, m.p. 128°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04859229 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-408464ca3ef44bdfb2f5103ae0bc6498 |
| Source note | uspto-grants-1989_08 |