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HRID1722941

反应详情

EQUATION

反应方程式

HRID 1722941 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)/C(CC)=C(/C)N
HCID10630766

未命名化合物

结构：CC(C)Oc1cc(N=C=O)c(F)cc1Cl
HCID13272924

4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate

C10H9ClFNO2

PRODUCTS

生成物

1
结构：CCOC(=O)/C(CC)=C(/C)NC(=O)Nc1cc(OC(C)C)c(Cl)cc1F
HCID70395854

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

using 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate in dimethylformamide with ethyl 3-amino-2-ethylcrotonate there is obtained ethyl 2-ethyl-3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-crotonate, m.p. 112°-114° C. and from this intermediate with sodium hydride in dimethylformamide there is obtained 5-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-methyl-2,4(1H,3H)-pyrimidinedione, m.p. 128°-130° C.