Dimethyl Sulfate → 2,4(1H,3H)-Pyrimidinedione, 3-(4-chloro-5-ethoxy-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-

HRID 1722944Notes

Reaction equation

[CH2:1]([O:3][C:4]1[C:5]([Cl:23])=[CH:6][C:7]([F:22])=[C:8]([N:10]2[C:15](=[O:16])[CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[NH:12][C:11]2=[O:21])[CH:9]=1)[CH3:2].S(OC)(O[CH3:28])(=O)=O>>[CH2:1]([O:3][C:4]1[C:5]([Cl:23])=[CH:6][C:7]([F:22])=[C:8]([N:10]2[C:15](=[O:16])[CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[N:12]([CH3:28])[C:11]2=[O:21])[CH:9]=1)[CH3:2]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 20025910HCID 20025910, compound

Product 1

HCID 1353982,4(1H,3H)-Pyrimidinedione, 3-(4-chloro-5-ethoxy-2-fluorophenyl)-1-methyl-6-(trifluoromethyl)-

Procedure

using 3-(5-ethoxy-4-chloro-2-fluorophenyl)-6-trifluoromethyl- 2,4(1H,3H)-pyrimidinedione and dimethyl sulphate there is obtained 3-(5-ethoxy-4-chloro-2-fluorophenyl)-1-methyl-6 -trifluoromethyl-2,4(1H,3H)-pyrimidinedione, m.p. 118°-121° C.;

Sources & evidence

ORD record: ord-b444889118394297863ec29961bea310
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04859229

Reaction notes

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