Dimethyl Sulfate → HCID 15906747, compound

HRID 1722946Notes

Reaction equation

[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[C:13]([N:17]2[C:22](=[O:23])[CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[NH:19][C:18]2=[O:28])=[CH:12][C:3]=1[O:4][CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7].S(OC)(O[CH3:33])(=O)=O>>[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[C:13]([N:17]2[C:22](=[O:23])[CH:21]=[C:20]([C:24]([F:25])([F:26])[F:27])[N:19]([CH3:33])[C:18]2=[O:28])=[CH:12][C:3]=1[O:4][CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 15545047HCID 15545047, compound

Product 1

HCID 15906747HCID 15906747, compound

Procedure

using ethyl 2-[2-chloro-5-(3,6-dihydro-2,6-dioxo-4-trifluoromethyl-1(2H)-pyrimidinyl)-4-fluorophenoxy]-propionate and dimethyl sulphate there is obtained ethyl 2-[2-chloro-5-(3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl)-4-fluorophenoxy]-propionate, 1H-NMR (CDCl3, 400 MHz): 7.32 ppm (d,1H), 6.83 ppm (d,0.5H), 6.81 ppm (d,0.5H), 6.34 ppm (2s,1H), 4.53-4.72 ppm (m,1H), 4.13-4.27 ppm (m,2H), 3.50-3.59 ppm (m,3H), 1.67 ppm (d,3H), 1.18-1.28 ppm (m.3H):

Sources & evidence

ORD record: ord-086dd34db2d945fd9fcfd3c4c0e2b05a
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04859229

Reaction notes

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