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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1722955Generated: October 31, 2026

Dimethyl Sulfate → HCID 20026041, compound

https://huagongshe.com/reaction/1722955

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfateHCID 6497—
ReactantSodium hydrideHCID 24758—
ReactantHCID 14280058HCID 14280058—
SolventDimethylformamideHCID 6228—
ProductHCID 20026041HCID 20026041—

Reaction Steps

usinq 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione with dimethyl sulphate and sodium hydride in dimethylformamide there is obtained 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-1-methyl-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione, m.p. 143°-145° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04859229
Source datasetuspto-grants-1989_08
ORD IDord-856717bbc74b46a0b6605768ca00918c
Source noteuspto-grants-1989_08