Dimethyl Sulfate → HCID 20026041, compound

HRID 1722955Notes

Reaction equation

HRID 1722955 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:21](=[O:22])[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[NH:14][C:13]2=[O:23])=[C:4]([F:24])[CH:3]=1.S(OC)(O[CH3:29])(=O)=O.[H-].[Na+]>CN(C)C=O>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:21](=[O:22])[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[N:14]([CH3:29])[C:13]2=[O:23])=[C:4]([F:24])[CH:3]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 24758Sodium hydrideHCID 14280058HCID 14280058, compound

Product 1

HCID 20026041HCID 20026041, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

usinq 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione with dimethyl sulphate and sodium hydride in dimethylformamide there is obtained 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-1-methyl-5,6,7,8-tetrahydro-2,4(1H,3H)-quinazolinedione, m.p. 143°-145° C.

Sources & evidence

ORD record
ord-856717bbc74b46a0b6605768ca00918c
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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