Methyl iodide → HCID 21265627, compound

HRID 1722958Notes

Reaction equation

HRID 1722958 reaction equation
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1.[C:23](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[Br:1][C:2]1[C:7]([O:8][CH3:23])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 11372498HCID 11372498, compound

Product 1

HCID 21265627HCID 21265627, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

using 3-(4-bromo-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with potassium carbonate and methyl iodide in acetonitrile there is obtained 3-(4-bromo-2-fluoro-5-methoxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione. m.p. 154° C.;

Sources & evidence

ORD record
ord-cb96fbf38c73429593cd1c64cf11a4c2
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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