2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 20026086, compound

HRID 1722980Notes

Reaction equation

HRID 1722980 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([NH:6][C:7](=O)[O:8]CC)=[C:4]([F:14])[CH:3]=1.[NH2:15]/[C:16](/[CH3:23])=[CH:17]\[C:18]([O:20]CC)=O>>[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([N:6]2[C:18](=[O:20])[CH:17]=[C:16]([CH3:23])[NH:15][C:7]2=[O:8])=[C:4]([F:14])[CH:3]=1

Participants

3

Reactant 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 887936Ethyl (4-chloro-2-fluorophenyl)carbamate

Product 1

HCID 20026086HCID 20026086, compound

Procedure

In an analogous manner, starting from ethyl 4-chloro-2-fluorocarbanilate and ethyl 3-aminocrotonate there is obtained 3-(4-chloro-2-fluorophenyl)-6-methyl-2,4(1H,3H) -pyrimidinedione. m.p. >220° C.; mass spectrum (m/e): 254 (M+), 235, 219, 17, 143, 108, 83, 68, 42;

Sources & evidence

ORD record
ord-2338bd8a9fc74c608c918f4b555ff498
Source dataset
uspto-grants-1989_08
Patent number
US04859229

Reaction notes

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