Ethanol → N-chloroacetamidomethyl acrylamide N-acrylamidomethyl-2-oxopyrrolidine

HRID 1722990Notes

Reaction equation

HRID 1722990 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][NH:7][C:8](=[O:11])[CH:9]=[CH2:10])=[O:4].[C:12]([NH:16][CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][C:19]1=[O:23])(=[O:15])[CH:13]=[CH2:14].C(O)C.N(C(C)(C)C#N)=NC(C)(C)C#N>O>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][NH:7][C:8](=[O:11])[CH:9]=[CH2:10])=[O:4].[C:12]([NH:16][CH2:17][N:18]1[CH2:22][CH2:21][CH2:20][C:19]1=[O:23])(=[O:15])[CH:13]=[CH2:14]

Participants

6

Reactant 4

HCID 702EthanolHCID 6547AzobisisobutyronitrileHCID 18414899Acrylamidomethyl 2-oxopyrrolidineHCID 86205169N-chloroacetamidomethyl acrylamide

Product 1

HCID 86743306N-chloroacetamidomethyl acrylamide N-acrylamidomethyl-2-oxopyrrolidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

18 g of N-chloroacetamidomethyl acrylamide, 18 g of acrylamidomethyl 2-oxopyrrolidine, 144 g of ethanol, 144 g of water and 1.8 g of azobis-iso-butyronitrile are placed in a reactor. The mixture is heated under a nitrogen blanket for 2 hours with constant stirring.

Workup

  1. temperatureThe mixture is heated under a nitrogen blanket for 2 hours with constant stirring

Sources & evidence

ORD record
ord-999f4e73c23942a3b612e5f1918bb1d4
Source dataset
uspto-grants-1989_08
Patent number
US04859460

Reaction notes

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