Sodium Hydroxide → 2,6-Dimethyl-1-oxo-4-(thiomorpholin-4-yl)-1lambda~5~-pyridine-3-carboxamide

HRID 1722998Notes

Reaction equation

HRID 1722998 reaction equation
Cl.[C:2]([C:4]1[C:5]([CH3:18])=[N+:6]([O-:17])[C:7]([CH3:16])=[CH:8][C:9]=1[N:10]1[CH2:15][CH2:14][S:13][CH2:12][CH2:11]1)#[N:3].[OH-:19].[Na+]>>[CH3:18][C:5]1[C:4]([C:2]([NH2:3])=[O:19])=[C:9]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[CH:8]=[C:7]([CH3:16])[N+:6]=1[O-:17]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 3064968HCID 3064968, compound

Product 1

HCID 136880552,6-Dimethyl-1-oxo-4-(thiomorpholin-4-yl)-1lambda~5~-pyridine-3-carboxamide

Procedure

3 g (0.012 mol) of 3-cyano-2,6-dimethyl-4-(4-thiomorpholinyl)pyridine 1-oxide hydrochloride (from Example 1) were dissolved in 10 ml of 10 N sodium hydroxide solution, and the solution was heated under reflux for 6 hours. It was then evaporated until a precipitate formed, the mixture was cooled, and the solid was filtered off and recrystallized from methanol.

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 6 hours
  3. customIt was then evaporated until a precipitate
  4. customformed
  5. temperaturethe mixture was cooled
  6. filtrationthe solid was filtered off
  7. customrecrystallized from methanol

Sources & evidence

ORD record
ord-f8f3bb67e8fc4dc4b8aa764bf2d64f62
Source dataset
uspto-grants-1989_08
Patent number
US04859663

Reaction notes

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