Sodium Hydroxide → 2,6-Dimethyl-1-oxo-4-(thiomorpholin-4-yl)-1lambda~5~-pyridine-3-carboxamide

Participants

Reaction Steps

3 g (0.012 mol) of 3-cyano-2,6-dimethyl-4-(4-thiomorpholinyl)pyridine 1-oxide hydrochloride (from Example 1) were dissolved in 10 ml of 10 N sodium hydroxide solution, and the solution was heated under reflux for 6 hours. It was then evaporated until a precipitate formed, the mixture was cooled, and the solid was filtered off and recrystallized from methanol.

Provenance & Evidence