反应详情

To a stirred mixture of 130 ml of ether, 130 ml of water and 10.0 g of 2-ethylphenol was added dropwise 6.7 ml of 61% nitric acid, and the reaction was continued with stirring at room temperature for 4 hours. The reaction mixture was extracted with 300 ml of ethyl acetate and washed with a brine, and then dried with anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away under reduced pressure. The residue was purified by subjecting to silica-gel column-chromatography [eluent: chloroform]to give 5.75 g of 6-ethyl-2-nitrophenol.

1. extractionThe reaction mixture was extracted with 300 ml of ethyl acetate
2. washwashed with a brine
3. dry with materialdried with anhydrous sodium sulfate
4. filtrationThe drying agent was filtered off
5. distillationthe solvent was distilled away under reduced pressure
6. customThe residue was purified