Uracil → HCID 21121131, compound

HRID 1723023Notes

Reaction equation

HRID 1723023 reaction equation
[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:18][N:19]2[CH2:23][C:22](=[O:24])[NH:21][C:20]2=[O:25])[CH2:3]1.N1C=CC(=[O:32])NC1=O>>[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][C@@H:4]([CH2:18][N+:19]2([O-:32])[CH2:23][C:22](=[O:24])[NH:21][C:20]2=[O:25])[CH2:3]1

Participants

3

Reactant 2

HCID 1174UracilHCID 1257204-Hydroxy-1-[(6-methylergolin-8-yl)methyl]-1,5-dihydro-2H-imidazol-2-one

Product 1

HCID 21121131HCID 21121131, compoundYield 63%

Procedure

Repeating Example 1 but using 1-[(6-methylergolin -8β- yl)methyl]-2,4-imidazolidinedione instead of 1-[(6-methyl -Δ- 9,10-ergolen -8β- methyl]-2,4-(1H,3H)-pyrimidinedione the title compound was obtained in 63% yield, m.p. 163-165° C.

Sources & evidence

ORD record
ord-57bb00a1b2934812b0df201207b39347
Source dataset
uspto-grants-1989_08
Patent number
US04859678

Reaction notes

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