Hydrochloric Acid → HCID 20026642, compound

Participants

Reaction Steps

(a-5) A mixture of 4.2 parts of ethyl 6-(hydroxymethyl)-1-methoxy-1H-benzimidazole-2-carboxylate and 60 parts of concentrated hydrochloric acid was stirred for 1 hour at reflux temperature. The reaction mixture was concentrated and the residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 3.1 parts (79.2%) of 6-(chloromethyl)-1-methoxy-1H-benzimidazole monohydrochloride; mp. 158° C. (int. 33).

Provenance & Evidence