反应详情

(a-5) A mixture of 4.2 parts of ethyl 6-(hydroxymethyl)-1-methoxy-1H-benzimidazole-2-carboxylate and 60 parts of concentrated hydrochloric acid was stirred for 1 hour at reflux temperature. The reaction mixture was concentrated and the residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 3.1 parts (79.2%) of 6-(chloromethyl)-1-methoxy-1H-benzimidazole monohydrochloride; mp. 158° C. (int. 33).

1. temperatureat reflux temperature
2. concentrationThe reaction mixture was concentrated
3. customthe residue was crystallized from 2-propanol
4. filtrationThe product was filtered off
5. customdried