Hydrochloric Acid → HCID 20026642, compound

HRID 1723099Notes

Reaction equation

HRID 1723099 reaction equation
O[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9](C(OCC)=O)[N:8]([O:16][CH3:17])[C:7]=2[CH:18]=1.[ClH:19]>>[ClH:19].[Cl:19][CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[CH:9][N:8]([O:16][CH3:17])[C:7]=2[CH:18]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14518380HCID 14518380, compound

Product 1

HCID 20026642HCID 20026642, compoundYield 79.2%

Procedure

(a-5) A mixture of 4.2 parts of ethyl 6-(hydroxymethyl)-1-methoxy-1H-benzimidazole-2-carboxylate and 60 parts of concentrated hydrochloric acid was stirred for 1 hour at reflux temperature. The reaction mixture was concentrated and the residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 3.1 parts (79.2%) of 6-(chloromethyl)-1-methoxy-1H-benzimidazole monohydrochloride; mp. 158° C. (int. 33).

Workup

  1. temperatureat reflux temperature
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was crystallized from 2-propanol
  4. filtrationThe product was filtered off
  5. customdried

Sources & evidence

ORD record
ord-c5fb85c447a94dbdad243c4fcd389313
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

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