Thionyl Chloride → HCID 178432159, compound

HRID 1723101Notes

Reaction equation

HRID 1723101 reaction equation
[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([CH:9]([C:11]2[CH:20]=[CH:19][C:14]3[NH:15][C:16]([CH3:18])=[N:17][C:13]=3[CH:12]=2)O)[CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:23])=O>>[ClH:23].[Cl:1][CH:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([F:2])[CH:4]=1)[C:11]1[CH:20]=[CH:19][C:14]2[NH:15][C:16]([CH3:18])=[N:17][C:13]=2[CH:12]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178432211HCID 178432211, compound

Product 1

HCID 178432159HCID 178432159, compoundYield 86.8%

Procedure

(b-1) A mixture of 13 parts of α-(3-fluorophenyl)-2-methyl-1H-benzimidazole-5-methanol monohydrochloride and 81 parts of thionyl chloride was stirred overnight at room temperature. The reaction mixture was concentrated to dry, yielding 12 parts (86.8%) of 5-[chloro(3-fluorophenyl)methyl]-2-methyl-1H-benzimidazole monohydrochloride as a residue (int. 45).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customto dry

Sources & evidence

ORD record
ord-fb8f6744abc14f34a0f833edd5b97cd8
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

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