Thionyl Chloride → HCID 178432159, compound

Participants

Reaction Steps

(b-1) A mixture of 13 parts of α-(3-fluorophenyl)-2-methyl-1H-benzimidazole-5-methanol monohydrochloride and 81 parts of thionyl chloride was stirred overnight at room temperature. The reaction mixture was concentrated to dry, yielding 12 parts (86.8%) of 5-[chloro(3-fluorophenyl)methyl]-2-methyl-1H-benzimidazole monohydrochloride as a residue (int. 45).

Provenance & Evidence