Thionyl Chloride → HCID 20026612, compound

HRID 1723106Notes

Reaction equation

HRID 1723106 reaction equation
[C:1]1([C:7]2[N:11]([CH2:12][CH2:13][CH3:14])[C:10]3[CH:15]=[CH:16][C:17]([C:19]([OH:21])=O)=[CH:18][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:24])=O>ClC(Cl)Cl>[ClH:24].[C:1]1([C:7]2[N:11]([CH2:12][CH2:13][CH3:14])[C:10]3[CH:15]=[CH:16][C:17]([C:19]([Cl:24])=[O:21])=[CH:18][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 5073640HCID 5073640, compound

Product 1

HCID 20026612HCID 20026612, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

(a-2) To a stirred solution of 112.13 parts of 2-phenyl-1-propyl-1H-benzimidazole-5-carboxylic acid in 525 parts of trichloromethane were added 142 parts of thionyl chloride. Stirring was continued for 30 minutes at reflux temperature. The reaction mixture was evaporated, yielding 134 parts (100%) of 2-phenyl-1-propyl-1H-benzimidazole-5-carbonyl chloride monohydrochloride as a residue (int. 58).

Workup

  1. temperatureat reflux temperature
  2. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-97c067ebdd334f89ad0a7b8e15d328da
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

Loading…