Thiophene → HCID 54395078, compound

HRID 1723113Notes

Reaction equation

HRID 1723113 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([NH:13][CH2:14][C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)=[C:9]([N+:21]([O-])=O)[CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.S1C=CC=C1.[H][H]>CO.[Pt]>[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([NH2:21])[C:10]([NH:13][CH2:14][C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)=[CH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

6

Reactant 3

HCID 8030ThiopheneHCID 14518368HCID 14518368, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54395078HCID 54395078, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent2×

Procedure

(b-1) A mixture of 6.2 parts of N-[4-(1H-imidazol-1-ylmethyl)-2-nitrophenyl]-3-pyridinemethanamine, 1 part of a solution of thiophene in methanol 4% and 200 parts of methanol was hydrogenated at normal pressure and at 50° C. with 2 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 5.6 parts (100%) of 4-(1H-imidazol-1-ylmethyl)-N1 -(3-pyridinylmethyl)-1,2-benzenediamine as a residue (int. 80).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-915f41b09b164113b14c39da1e34b995
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

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