Methylamine → 1-[4-(Methylamino)-3-nitrophenyl]ethan-1-one

HRID 1723114Notes

Reaction equation

HRID 1723114 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[CH3:14][NH2:15]>CO>[CH3:14][NH:15][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 795964'-Chloro-3'-nitroacetophenone

Product 1

HCID 131756261-[4-(Methylamino)-3-nitrophenyl]ethan-1-oneYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

(a-1) To a stirred and cooled solution of 50 parts of 1-(4-chloro-3-nitrophenyl)ethanone in 240 parts of methanol was added a solution of 40 parts of methanamine in 160 parts of methanol. The reaction mixture was stirred for 12 hours at 60° C. The reaction mixture was evaporated to dry, yielding 50 parts (100%) of 1-[4-(methylamino)-3-nitrophenyl]ethanone as a residue (int. 87).

Workup

  1. stirringThe reaction mixture was stirred for 12 hours at 60° C
  2. customThe reaction mixture was evaporated
  3. customto dry

Sources & evidence

ORD record
ord-a749817a966d41bf9cb3b6cc15d92089
Source dataset
uspto-grants-1989_08
Patent number
US04859684

Reaction notes

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