Hydrochloric Acid → HCID 178478894, compound

Participants

Reaction Steps

A mixture of 3 parts of ethyl 4-[5-(1H-imidazol-1-ylmethyl)-1H-benzimidazol-2-yl]benzoate and 50 parts of a hydrochloric acid solution 6N was stirred and refluxed for 12 hours. The reaction mixture was evaporated to dry. The residue was taken up in 2 parts of water and 2-propanone. The product was filtered off and dried, yielding 2 parts (59%) of 4-[5-(1H-imidazol-1-ylmethyl)-1H-benzimidazol-2-yl]benzoic acid dihydrochloride. monohydrate; mp. 288.2° C. (compound 259).

Provenance & Evidence